topics / small-molecule

Tagged small-molecule.

Animal only 5-Amino-1MQ A small-molecule NNMT inhibitor (not a peptide) studied for obesity and metabolic disease. The promising data are entirely in mice; there is no verifiable human trial and no approval.
No credible evidence DNP (2,4-Dinitrophenol) DNP is a synthetic mitochondrial uncoupler sold illegally as a 'fat burner' — never FDA-approved for human use, with no antidote and a long record of deaths. It is not a peptide and not a steroid.
Strong human Methylene Blue A synthetic redox dye with one strong, FDA-approved use (treating methemoglobinemia) and a long list of popular biohacking claims that human evidence does not support.
Strong human Orforglipron An oral, non-peptide (small-molecule) GLP-1 receptor agonist, FDA-approved in April 2026 as Foundayo for chronic weight management. It is a once-daily pill with no food or timing restrictions — not a peptide, and not an injectable.
Preliminary human Tesofensine Tesofensine is an investigational oral triple monoamine (noradrenaline/dopamine/serotonin) reuptake inhibitor studied for obesity. It is a small molecule, not a peptide, and is not approved by any major regulator. It is banned in sport as a stimulant.