topics / melanocortin

Tagged melanocortin.

Preliminary human Afamelanotide (Melanotan-1): An Approved Orphan Drug With Modest, Single-Sponsor Evidence Afamelanotide is an FDA- and EMA-approved implant for a rare light-sensitivity disease. The trial evidence is real but modest, and it is not the gray-market tanning drug.
Preliminary human Melanotan II: It Tans, But It's Unapproved and Carries Real Harms A synthetic tanning peptide that does something, but is unapproved, unregulated, and tied to serious harms from priapism to melanoma case reports.
Strong human PT-141 (Bremelanotide / Vyleesi) An FDA-approved melanocortin agonist for low sexual desire in premenopausal women. Two real Phase 3 trials show a small, genuine benefit for that one use; almost everything else people take it for is unstudied.
Strong human Setmelanotide (Imcivree): Strong Evidence in Rare Obesity, None Beyond It An FDA-approved peptide for a handful of rare genetic and acquired forms of severe obesity, with no credible evidence for general weight loss.