Compare · GH secretagogue
Sermorelin vs Tesamorelin
Both are gh secretagogue compounds. Here's how they line up on the evidence — graded the same way.
| Sermorelin | Tesamorelin | |
|---|---|---|
| Evidence | 8/10 | 8/10 |
| Class | GH secretagogue | GH secretagogue |
| Summary | Sermorelin is a synthetic GHRH fragment that nudges the pituitary to release growth hormone; human data is old and thin, with no modern anti-aging RCTs. | Tesamorelin is an FDA-approved GHRH analogue with solid RCT evidence for shrinking visceral fat in HIV-associated lipodystrophy, but little proof outside that group. |
| Full profile → | Full profile → |
Sermorelin
Sermorelin is one of the oldest peptides in the "growth hormone" group, and unlike most of its cousins it actually held FDA approval at one point. People often lean on that history to suggest it does more than the evidence really backs up.
Tesamorelin
Tesamorelin, sold as Egrifta, is one of the few peptides in this space that actually has strong, FDA-grade human evidence behind it. The catch: almost all of that evidence comes from one specific group of patients. And a lot of the way the compound gets marketed elsewhere goes well past what those…