Compare · GH secretagogue
Sermorelin vs Tesamorelin
Both are gh secretagogue compounds. Here's how they line up on the evidence — graded the same way.
| Sermorelin | Tesamorelin | |
|---|---|---|
| Evidence | Preliminary human | Strong human |
| Class | GH secretagogue | GH secretagogue |
| Summary | Sermorelin is a synthetic GHRH fragment that nudges the pituitary to release growth hormone; human data is old and thin, with no modern anti-aging RCTs. | Tesamorelin is an FDA-approved GHRH analogue with solid RCT evidence for shrinking visceral fat in HIV-associated lipodystrophy, but little proof outside that group. |
| Full profile → | Full profile → |
Sermorelin
Sermorelin is one of the oldest peptides in the "growth hormone" category, and unlike most of its peers it once held FDA approval. That history is often used to imply more about its benefits than the evidence supports.
Tesamorelin
Tesamorelin, sold as Egrifta, is one of the few peptides in this space with genuine, FDA-grade human evidence behind it. The catch is that the evidence is almost entirely confined to one specific medical population, and a lot of how the compound is marketed elsewhere goes well beyond what those…