Independent reference & toolkit 100 compounds graded · Last reviewed June 2026

Compare · SARM

Testolone vs S23

Both are sarm compounds. Here's how they line up on the evidence — graded the same way.

TestoloneS23
Evidence 3/10 3/10
ClassSARMSARM
SummaryAn investigational, non-approved selective androgen receptor modulator (SARM) with no published human efficacy evidence for fitness use, a documented serious liver-injury case, and prohibited status in sport.S23 is a synthetic selective androgen receptor modulator (SARM) — not a peptide — studied only in rodents as a male contraceptive candidate. There are no human trials, and it is an unapproved drug banned in sport.
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Testolone

Testolone (RAD-140) is a selective androgen receptor modulator, or SARM (a drug that switches on the body's testosterone-sensing receptor in a targeted way). It is a small molecule made in a lab — not a peptide, and not an anabolic steroid. It was created as an experimental drug, was never approved…

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S23

S23 is a lab-made drug in a family called SARMs (selective androgen receptor modulators — molecules that switch on the same cell "docking points" as testosterone, but only in certain tissues). It is not a peptide. The idea behind it was to build up muscle and bone while having relatively little…

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