Compare · GH secretagogue
MK-677 vs Tesamorelin
Both are gh secretagogue compounds. Here's how they line up on the evidence — graded the same way.
| MK-677 | Tesamorelin | |
|---|---|---|
| Evidence | Preliminary human | Strong human |
| Class | GH secretagogue | GH secretagogue |
| Summary | MK-677 reliably raises growth hormone and IGF-1, but disease trials failed and one was stopped for a heart-failure signal. Investigational, never approved. | Tesamorelin is an FDA-approved GHRH analogue with solid RCT evidence for shrinking visceral fat in HIV-associated lipodystrophy, but little proof outside that group. |
| Full profile → | Full profile → |
MK-677
MK-677, also called ibutamoren, is one of the more unusual entries in any peptide reference — because it is not a peptide. It is a synthetic small molecule that fools the body into releasing more of its own growth hormone, and unlike most compounds marketed to the fitness and "anti-aging" crowd, it…
Tesamorelin
Tesamorelin, sold as Egrifta, is one of the few peptides in this space with genuine, FDA-grade human evidence behind it. The catch is that the evidence is almost entirely confined to one specific medical population, and a lot of how the compound is marketed elsewhere goes well beyond what those…