Compare · GH secretagogue
MK-677 vs Tesamorelin
Both are gh secretagogue compounds. Here's how they line up on the evidence — graded the same way.
| MK-677 | Tesamorelin | |
|---|---|---|
| Evidence | 7/10 | 8/10 |
| Class | GH secretagogue | GH secretagogue |
| Summary | MK-677 reliably raises growth hormone and IGF-1, but disease trials failed and one was stopped for a heart-failure signal. Investigational, never approved. | Tesamorelin is an FDA-approved GHRH analogue with solid RCT evidence for shrinking visceral fat in HIV-associated lipodystrophy, but little proof outside that group. |
| Full profile → | Full profile → |
MK-677
MK-677, also called ibutamoren, is one of the odder entries you'll find in any peptide reference — because it isn't actually a peptide. It's a man-made molecule that tricks the body into releasing more of its own growth hormone. And unlike most of the products sold to the fitness and "anti-aging"…
Tesamorelin
Tesamorelin, sold as Egrifta, is one of the few peptides in this space that actually has strong, FDA-grade human evidence behind it. The catch: almost all of that evidence comes from one specific group of patients. And a lot of the way the compound gets marketed elsewhere goes well past what those…