Compare · GH secretagogue
MK-677 vs Sermorelin
Both are gh secretagogue compounds. Here's how they line up on the evidence — graded the same way.
| MK-677 | Sermorelin | |
|---|---|---|
| Evidence | Preliminary human | Preliminary human |
| Class | GH secretagogue | GH secretagogue |
| Summary | MK-677 reliably raises growth hormone and IGF-1, but disease trials failed and one was stopped for a heart-failure signal. Investigational, never approved. | Sermorelin is a synthetic GHRH fragment that nudges the pituitary to release growth hormone; human data is old and thin, with no modern anti-aging RCTs. |
| Full profile → | Full profile → |
MK-677
MK-677, also called ibutamoren, is one of the more unusual entries in any peptide reference — because it is not a peptide. It is a synthetic small molecule that fools the body into releasing more of its own growth hormone, and unlike most compounds marketed to the fitness and "anti-aging" crowd, it…
Sermorelin
Sermorelin is one of the oldest peptides in the "growth hormone" category, and unlike most of its peers it once held FDA approval. That history is often used to imply more about its benefits than the evidence supports.