Compare · GH secretagogue
MK-677 vs Sermorelin
Both are gh secretagogue compounds. Here's how they line up on the evidence — graded the same way.
| MK-677 | Sermorelin | |
|---|---|---|
| Evidence | 7/10 | 8/10 |
| Class | GH secretagogue | GH secretagogue |
| Summary | MK-677 reliably raises growth hormone and IGF-1, but disease trials failed and one was stopped for a heart-failure signal. Investigational, never approved. | Sermorelin is a synthetic GHRH fragment that nudges the pituitary to release growth hormone; human data is old and thin, with no modern anti-aging RCTs. |
| Full profile → | Full profile → |
MK-677
MK-677, also called ibutamoren, is one of the odder entries you'll find in any peptide reference — because it isn't actually a peptide. It's a man-made molecule that tricks the body into releasing more of its own growth hormone. And unlike most of the products sold to the fitness and "anti-aging"…
Sermorelin
Sermorelin is one of the oldest peptides in the "growth hormone" group, and unlike most of its cousins it actually held FDA approval at one point. People often lean on that history to suggest it does more than the evidence really backs up.