Compare · Melanocortin
Melanotan II vs Setmelanotide
Both are melanocortin compounds. Here's how they line up on the evidence — graded the same way.
| Melanotan II | Setmelanotide | |
|---|---|---|
| Evidence | 6/10 | 10/10 |
| Class | Melanocortin | Melanocortin |
| Summary | A synthetic tanning peptide that does something, but is unapproved, unregulated, and tied to serious harms from priapism to melanoma case reports. | An FDA-approved peptide for a handful of rare genetic and acquired forms of severe obesity, with no credible evidence for general weight loss. |
| Full profile → | Full profile → |
Melanotan II
Melanotan II is a man-made peptide sold online to darken skin (people call it "the tan jab"), curb appetite, and boost sex drive. No country has approved it as a drug, and the way people actually use it has never been put through a proper, controlled study.
Setmelanotide
Setmelanotide, sold as Imcivree, is a prescription peptide used to treat a small number of rare, clearly defined forms of severe obesity. For those specific conditions, the evidence is genuinely strong. But step outside them — to general weight loss, fat loss, or "speeding up your metabolism" in…