Independent reference & toolkit 100 compounds graded · Last reviewed June 2026

Compare · SARM

LGD-3303 vs S23

Both are sarm compounds. Here's how they line up on the evidence — graded the same way.

LGD-3303S23
Evidence 3/10 3/10
ClassSARMSARM
SummaryLGD-3303 is a nonsteroidal selective androgen receptor modulator (SARM), not a peptide. Its evidence is preclinical (rodent and equine) only — there are no human trials. It is an unapproved research chemical and is banned at all times in sport.S23 is a synthetic selective androgen receptor modulator (SARM) — not a peptide — studied only in rodents as a male contraceptive candidate. There are no human trials, and it is an unapproved drug banned in sport.
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LGD-3303

LGD-3303 is a SARM — a selective androgen receptor modulator (a lab-made molecule that switches on the body's androgen, or male-hormone, receptors in some tissues but not others). It is not a peptide, and it is not a steroid. It came out of the same Ligand Pharmaceuticals research program as…

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S23

S23 is a lab-made drug in a family called SARMs (selective androgen receptor modulators — molecules that switch on the same cell "docking points" as testosterone, but only in certain tissues). It is not a peptide. The idea behind it was to build up muscle and bone while having relatively little…

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