Compare · GH secretagogue
Ipamorelin vs Tesamorelin
Both are gh secretagogue compounds. Here's how they line up on the evidence — graded the same way.
| Ipamorelin | Tesamorelin | |
|---|---|---|
| Evidence | Preliminary human | Strong human |
| Class | GH secretagogue | GH secretagogue |
| Summary | A selective growth-hormone-releasing peptide with early human safety data but a failed efficacy trial; never approved and banned in sport. | Tesamorelin is an FDA-approved GHRH analogue with solid RCT evidence for shrinking visceral fat in HIV-associated lipodystrophy, but little proof outside that group. |
| Full profile → | Full profile → |
Ipamorelin
Ipamorelin is a synthetic peptide that briefly raises growth hormone (GH) levels. It has been tested in humans, but the one trial that measured a real clinical outcome did not work, and it has never been approved for any use.
Tesamorelin
Tesamorelin, sold as Egrifta, is one of the few peptides in this space with genuine, FDA-grade human evidence behind it. The catch is that the evidence is almost entirely confined to one specific medical population, and a lot of how the compound is marketed elsewhere goes well beyond what those…