Compare · GH secretagogue
Ipamorelin vs Sermorelin
Both are gh secretagogue compounds. Here's how they line up on the evidence — graded the same way.
| Ipamorelin | Sermorelin | |
|---|---|---|
| Evidence | Preliminary human | Preliminary human |
| Class | GH secretagogue | GH secretagogue |
| Summary | A selective growth-hormone-releasing peptide with early human safety data but a failed efficacy trial; never approved and banned in sport. | Sermorelin is a synthetic GHRH fragment that nudges the pituitary to release growth hormone; human data is old and thin, with no modern anti-aging RCTs. |
| Full profile → | Full profile → |
Ipamorelin
Ipamorelin is a synthetic peptide that briefly raises growth hormone (GH) levels. It has been tested in humans, but the one trial that measured a real clinical outcome did not work, and it has never been approved for any use.
Sermorelin
Sermorelin is one of the oldest peptides in the "growth hormone" category, and unlike most of its peers it once held FDA approval. That history is often used to imply more about its benefits than the evidence supports.