Compare · GH secretagogue
Ipamorelin vs MK-677
Both are gh secretagogue compounds. Here's how they line up on the evidence — graded the same way.
| Ipamorelin | MK-677 | |
|---|---|---|
| Evidence | 6/10 | 7/10 |
| Class | GH secretagogue | GH secretagogue |
| Summary | A selective growth-hormone-releasing peptide with early human safety data but a failed efficacy trial; never approved and banned in sport. | MK-677 reliably raises growth hormone and IGF-1, but disease trials failed and one was stopped for a heart-failure signal. Investigational, never approved. |
| Full profile → | Full profile → |
Ipamorelin
Ipamorelin is a lab-made peptide (a short chain of amino acids, the building blocks of proteins) that briefly nudges up your body's growth hormone (GH). It has been tested in people, but the one trial that checked for a real-world health benefit didn't pan out, and it has never been approved for…
MK-677
MK-677, also called ibutamoren, is one of the odder entries you'll find in any peptide reference — because it isn't actually a peptide. It's a man-made molecule that tricks the body into releasing more of its own growth hormone. And unlike most of the products sold to the fitness and "anti-aging"…