Compare · GH secretagogue
Ipamorelin vs MK-677
Both are gh secretagogue compounds. Here's how they line up on the evidence — graded the same way.
| Ipamorelin | MK-677 | |
|---|---|---|
| Evidence | Preliminary human | Preliminary human |
| Class | GH secretagogue | GH secretagogue |
| Summary | A selective growth-hormone-releasing peptide with early human safety data but a failed efficacy trial; never approved and banned in sport. | MK-677 reliably raises growth hormone and IGF-1, but disease trials failed and one was stopped for a heart-failure signal. Investigational, never approved. |
| Full profile → | Full profile → |
Ipamorelin
Ipamorelin is a synthetic peptide that briefly raises growth hormone (GH) levels. It has been tested in humans, but the one trial that measured a real clinical outcome did not work, and it has never been approved for any use.
MK-677
MK-677, also called ibutamoren, is one of the more unusual entries in any peptide reference — because it is not a peptide. It is a synthetic small molecule that fools the body into releasing more of its own growth hormone, and unlike most compounds marketed to the fitness and "anti-aging" crowd, it…