Compare · Mitochondrial peptide
Humanin vs SS-31
Both are mitochondrial peptide compounds. Here's how they line up on the evidence — graded the same way.
| Humanin | SS-31 | |
|---|---|---|
| Evidence | 3/10 | 6/10 |
| Class | Mitochondrial peptide | Mitochondrial peptide |
| Summary | Humanin is a mitochondrial-derived peptide with interesting cell and animal data in aging and neuroprotection, but the human evidence is entirely observational — no interventional trial of administered humanin in people exists. It's unapproved and effectively uncharacterized for safety in humans. | Elamipretide won a narrow FDA accelerated approval for Barth syndrome in 2025, but its largest trials in myopathy, heart failure, and dry AMD all missed. |
| Full profile → | Full profile → |
Humanin
Humanin is one of the more scientifically intriguing peptides in the "longevity" corner of the gray market. It was the first mitochondrial-derived peptide ever found, it has a believable way of protecting cells, and the amount of it in your blood goes down as you age. But here's the catch: as of…
SS-31
SS-31, now approved as the drug elamipretide, is one of the more useful case studies on this site. It isn't some mystery ingredient dreamed up by supplement marketers — it's a genuine molecule that went through real, careful clinical trials. The honest lesson lies in what those trials found: in its…