Independent reference & toolkit 100 compounds graded · Last reviewed June 2026

Compare · GH secretagogue

Hexarelin vs Sermorelin

Both are gh secretagogue compounds. Here's how they line up on the evidence — graded the same way.

HexarelinSermorelin
Evidence 6/10 8/10
ClassGH secretagogueGH secretagogue
SummaryA synthetic ghrelin-mimicking peptide that reliably spikes growth hormone in small studies, but was never approved and is banned in sport.Sermorelin is a synthetic GHRH fragment that nudges the pituitary to release growth hormone; human data is old and thin, with no modern anti-aging RCTs.
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Hexarelin

Hexarelin is a lab-made peptide (a short chain of amino acids) that copies what the hunger hormone ghrelin does: it tells the body to release a quick, short burst of growth hormone (GH). Small human studies in the 1990s showed it does this dependably. But every one of those trials was tiny, brief,…

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Sermorelin

Sermorelin is one of the oldest peptides in the "growth hormone" group, and unlike most of its cousins it actually held FDA approval at one point. People often lean on that history to suggest it does more than the evidence really backs up.

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