Compare · GH secretagogue
Hexarelin vs MK-677
Both are gh secretagogue compounds. Here's how they line up on the evidence — graded the same way.
| Hexarelin | MK-677 | |
|---|---|---|
| Evidence | Preliminary human | Preliminary human |
| Class | GH secretagogue | GH secretagogue |
| Summary | A synthetic ghrelin-mimicking peptide that reliably spikes growth hormone in small studies, but was never approved and is banned in sport. | MK-677 reliably raises growth hormone and IGF-1, but disease trials failed and one was stopped for a heart-failure signal. Investigational, never approved. |
| Full profile → | Full profile → |
Hexarelin
Hexarelin is a synthetic peptide that mimics the hunger hormone ghrelin to provoke a sharp, short-lived burst of growth hormone (GH). Small human studies in the 1990s showed it does this reliably, but every trial was tiny, brief, and measured surrogate markers rather than real-world outcomes. It…
MK-677
MK-677, also called ibutamoren, is one of the more unusual entries in any peptide reference — because it is not a peptide. It is a synthetic small molecule that fools the body into releasing more of its own growth hormone, and unlike most compounds marketed to the fitness and "anti-aging" crowd, it…