Independent reference & toolkit 100 compounds graded · Last reviewed June 2026

Compare · GH secretagogue

GHRP-6 vs Sermorelin

Both are gh secretagogue compounds. Here's how they line up on the evidence — graded the same way.

GHRP-6Sermorelin
Evidence 6/10 8/10
ClassGH secretagogueGH secretagogue
SummaryAn old growth-hormone-releasing peptide that reliably raises GH and appetite in humans, but whose marketed muscle, fat-loss, and disease claims lack solid trials.Sermorelin is a synthetic GHRH fragment that nudges the pituitary to release growth hormone; human data is old and thin, with no modern anti-aging RCTs.
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GHRP-6

GHRP-6 is one of the oldest lab-made peptides designed to nudge the body into releasing growth hormone. The basics of what it does in people are genuinely well understood: it raises growth hormone (GH, a hormone that helps the body grow and repair tissue), and it makes people hungry. What is…

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Sermorelin

Sermorelin is one of the oldest peptides in the "growth hormone" group, and unlike most of its cousins it actually held FDA approval at one point. People often lean on that history to suggest it does more than the evidence really backs up.

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