Compare · GH secretagogue
GHRP-6 vs MK-677
Both are gh secretagogue compounds. Here's how they line up on the evidence — graded the same way.
| GHRP-6 | MK-677 | |
|---|---|---|
| Evidence | Preliminary human | Preliminary human |
| Class | GH secretagogue | GH secretagogue |
| Summary | An old growth-hormone-releasing peptide that reliably raises GH and appetite in humans, but whose marketed muscle, fat-loss, and disease claims lack solid trials. | MK-677 reliably raises growth hormone and IGF-1, but disease trials failed and one was stopped for a heart-failure signal. Investigational, never approved. |
| Full profile → | Full profile → |
GHRP-6
GHRP-6 is one of the oldest synthetic growth-hormone-releasing peptides, and its basic pharmacology in humans is genuinely well understood: it raises growth hormone (GH) and it makes people hungry. What is missing is the part that actually matters for the claims attached to it. For muscle growth,…
MK-677
MK-677, also called ibutamoren, is one of the more unusual entries in any peptide reference — because it is not a peptide. It is a synthetic small molecule that fools the body into releasing more of its own growth hormone, and unlike most compounds marketed to the fitness and "anti-aging" crowd, it…