Compare · GH secretagogue
GHRP-2 vs MK-677
Both are gh secretagogue compounds. Here's how they line up on the evidence — graded the same way.
| GHRP-2 | MK-677 | |
|---|---|---|
| Evidence | Preliminary human | Preliminary human |
| Class | GH secretagogue | GH secretagogue |
| Summary | GHRP-2 (pralmorelin) provokes a growth hormone pulse. It is an approved diagnostic in Japan, but the human therapeutic and anti-aging evidence is small and old. | MK-677 reliably raises growth hormone and IGF-1, but disease trials failed and one was stopped for a heart-failure signal. Investigational, never approved. |
| Full profile → | Full profile → |
GHRP-2
GHRP-2 is one of those compounds with a genuine, narrow medical use that has been stretched far past what the evidence supports. In Japan it is an approved diagnostic: a single dose provokes a measurable spike in growth hormone, which helps doctors test for growth hormone deficiency. Online, it is…
MK-677
MK-677, also called ibutamoren, is one of the more unusual entries in any peptide reference — because it is not a peptide. It is a synthetic small molecule that fools the body into releasing more of its own growth hormone, and unlike most compounds marketed to the fitness and "anti-aging" crowd, it…