Independent reference & toolkit 100 compounds graded · Last reviewed June 2026

Compare · GH secretagogue

CJC-1295 vs MK-677

Both are gh secretagogue compounds. Here's how they line up on the evidence — graded the same way.

CJC-1295MK-677
Evidence 6/10 7/10
ClassGH secretagogueGH secretagogue
SummaryA long-acting GHRH analog that raises GH and IGF-1 in short human trials, but has no clinical-outcome data, is not FDA-approved, and is banned in sport.MK-677 reliably raises growth hormone and IGF-1, but disease trials failed and one was stopped for a heart-failure signal. Investigational, never approved.
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CJC-1295

CJC-1295 is a lab-made copy of a natural hormone called GHRH (growth hormone-releasing hormone — the signal that tells your body to make growth hormone). It's built to nudge your body into releasing more of its own growth hormone (GH). Short studies in people confirm it does raise GH and IGF-1 (a…

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MK-677

MK-677, also called ibutamoren, is one of the odder entries you'll find in any peptide reference — because it isn't actually a peptide. It's a man-made molecule that tricks the body into releasing more of its own growth hormone. And unlike most of the products sold to the fitness and "anti-aging"…

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