Independent reference & toolkit 100 compounds graded · Last reviewed June 2026

Compare · PPARδ agonist

Cardarine vs GW-0742

Both are pparδ agonist compounds. Here's how they line up on the evidence — graded the same way.

CardarineGW-0742
Evidence 7/10 3/10
ClassPPARδ agonistPPARδ agonist
SummaryCardarine (GW-501516) is a synthetic PPARδ agonist, not a peptide or SARM, abandoned in development after rodent studies showed multi-organ cancer; it is banned in sport and has no approved human use.GW-0742 is a synthetic small-molecule PPARδ agonist and close sibling of cardarine (GW-501516) — not a peptide and not a SARM. It has no human efficacy data, a serious carcinogenicity concern inherited from its near-twin, and is banned in sport at all times.
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Cardarine

You'll often see Cardarine (GW-501516) sold and talked about right next to SARMs in the "research chemical" market. But it's actually a completely different kind of substance. It's a synthetic PPARδ agonist — not a peptide, and not a SARM. It got early attention as an "exercise mimetic" (a drug…

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GW-0742

GW-0742 is a lab-made molecule that switches on a cell receptor called PPARδ, and it's a close chemical cousin of cardarine (GW-501516). It often gets sold and talked about next to SARMs and peptides in the "research chemical" world, but it's neither of those — it's a small-molecule that latches…

Read the full evidence-graded GW-0742 profile →

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