Independent reference & toolkit 100 compounds graded · Last reviewed June 2026

Compare · SARM

Andarine vs Ligandrol

Both are sarm compounds. Here's how they line up on the evidence — graded the same way.

AndarineLigandrol
Evidence 3/10 7/10
ClassSARMSARM
SummaryA non-steroidal SARM with tissue-selective anabolic activity in rodents, but no completed human efficacy trials; clinical development was halted over vision side effects.Ligandrol (LGD-4033) is a nonsteroidal selective androgen receptor modulator (SARM), not a peptide. Its only real human data is a single 3-week Phase 1 trial; it is an unapproved drug, illegal to sell as a supplement, and banned in sport.
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Andarine

Andarine (S4) is a SARM — a selective androgen receptor modulator (a lab-made molecule designed to act on the body's testosterone-sensing system in a targeted way). It is a synthetic small molecule, not a peptide and not an anabolic steroid. You will often see it sold in fitness, biohacking, and…

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Ligandrol

Ligandrol (LGD-4033) is a SARM (selective androgen receptor modulator — a drug that turns on the same cell switch as testosterone, but only in some tissues). Importantly, it is a small lab-made molecule, not a peptide. It is sold widely online and is popular in fitness circles, where it is pitched…

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