Independent reference & toolkit 100 compounds graded · Last reviewed June 2026

Compare · Exercise mimetic

AICAR vs SLU-PP-332

Both are exercise mimetic compounds. Here's how they line up on the evidence — graded the same way.

AICARSLU-PP-332
Evidence 1/10 3/10
ClassExercise mimeticExercise mimetic
SummaryAICAR (acadesine) is a small-molecule AMPK activator — not a peptide — famous for making sedentary mice run farther, but with no credible human evidence for endurance, fat loss, or longevity. It is an unapproved experimental drug, banned in sport at all times.SLU-PP-332 is a synthetic small-molecule pan-agonist of the estrogen-related receptors (ERRα/β/γ) studied as an 'exercise mimetic' — not a peptide, and animal-stage only with no human data.
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AICAR

AICAR is a small molecule sold online as an "exercise in a pill." It is not a peptide, not a hormone, and not a SARM (selective androgen receptor modulator — a class of muscle-building drugs). It is an AICA-riboside that switches on a metabolic enzyme called AMPK. Its whole reputation comes from…

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SLU-PP-332

SLU-PP-332 is a lab-made molecule sold and talked about in the "research chemical" market as an "exercise mimetic" — a compound meant to switch on some of the body's responses to exercise without the workout. It often gets lumped in with peptides online, but it is not a peptide. It is a small…

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